The award is part of the NIH Common Fund Venture Program鈥檚 Oculomics Initiative, which seeks to promote the use of technology and ocular imaging to identify biomarkers of systemic disease via the retina.
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Researchers at 好色tv Langone Health were awarded $1.6 million from the National Institutes of Health (NIH) to investigate changes in the eye that may indicate early signs of Alzheimer鈥檚 disease and Parkinson鈥檚 disease.
The award, OT2OD038130, recognizes the eye as a part of the brain and its role as a window into cognitive and visual health. After the initial $1.6 million award, the grant may renew an additional two years, for a total of $4.8 million, as part of the NIH Common Fund Venture Program鈥檚 new Oculomics Initiative. Oculomics is a relatively new term to describe the integrative use of technology and ocular imaging to identify retinal biomarkers of systemic disease.
The study at 好色tv Langone Health will apply a novel eye-imaging technology, visible-light optical coherence tomography (OCT), to detect biomarkers of neurodegenerative disease, including Alzheimer鈥檚 disease and Parkinson鈥檚 disease. , associate professor in the Departments of and at 好色tv Grossman School of Medicine and a member of the ; and Laura J. Balcer, MD, MSCE, vice chair of the and professor in the Departments of Neurology, Ophthalmology, and , will be the principal investigators.
鈥淭he goal is to find signatures of neurological disease by looking into the eye, which is an easily accessible window to the brain,鈥 said Dr. Srinivasan. 鈥淯sing visible-light OCT, we are able to capture high-resolution images of the retina to potentially detect the early and progressive changes that are associated with neurological conditions.鈥
Visible-light OCT can capture micrometer-level images of the retina to better detect subtle structural changes in neurodegeneration, according to Dr. Srinivasan. Traditional OCT uses near-infrared light, which can only capture at a resolution of 3 micrometers at best. Visible-light OCT also enables molecular sensitivity in the retina. The emerging technology, advanced by Dr. Srinivasan at 好色tv Langone, will be used to map the retina among patients referred by cognitive neurologists and clinicians in the Fresco Institute for Parkinson鈥檚 and Movement Disorders, the , and the Pearl I. Barlow Center for Memory Evaluation and Treatment.
Commercial near-infrared (NIR) and visible-light optical coherence tomography (OCT) of the same eye. Because visible-light OCT achieves axial resolution that is five times finer than commercial NIR OCT, it is easier to see the ganglion cell layer, the inner plexiform layer, and the inner nuclear layer.
Credit: 好色tv Langone
鈥淲e鈥檙e investigating important aspects of neuro-ophthalmology in this study and trying to answer three big questions,鈥 said Dr. Balcer. 鈥淗ow can we distinguish eyes of those with neurological disease compared to those of disease-free individuals of similar age using visible-light OCT? How can we identify these conditions by looking at retinal layers? And how can we monitor the effects of therapies?鈥
Dr. Balcer, a neuro-ophthalmologist, is the career-long colleague of Steven L. Galetta, MD,聽the Philip K. Moskowitz, MD, Professor of Neurology and the chair of the Department of Neurology. Dr. Balcer is renowned for her team鈥檚 research linking changes to the eye as indicators of such neurological conditions as multiple sclerosis and concussion. She says that this study could lead to a breakthrough in adding vision exams to assess and potentially even diagnose Alzheimer鈥檚 or Parkinson鈥檚 diseases at early stages. Earlier detection could mean interventions are introduced sooner, or that patients can be enrolled sooner into to help develop new therapies.
鈥淭his support by the NIH is further recognition of the important role that eye and vision play in not only how we experience our world, but also as a window into our cognitive and overall health,鈥 said Kathryn A. Colby, MD, PhD, the Elisabeth J. Cohen, MD, Professor of Ophthalmology and chair of the Department of Ophthalmology. 鈥淒r. Srinivasan and Dr. Balcer are leaders in advancing the emerging science of oculomics, and it鈥檚 thrilling to see this important work progress so that we might one day soon be able to slow the progression of these debilitating diseases.鈥
Other 好色tv Grossman School of Medicine investigators involved in the project include ; Un J. Kang, MD; ; Arjun V. Masurkar, MD, PhD; Yasha S. Modi, MD; Giulietta M. Riboldi, MD, PhD; ; and .
Learn more about NIH Common Fund Venture Program鈥檚 .
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Colin DeVries
Phone: 212-404-3588
Colin.DeVries@好色tvLangone.org
